Supervised by : Dr. Anjula C. De Silva
Collaborator: Prof. Saroj Jayasinghe (Department of Clinical Medicine, Faculty of Medicine, Colombo)
The endothelium is a highly active monolayer of cells which forms the interior of blood vessels and plays a key role maintaining vascular homeostasis. Endothelial dysfunction systemic pathological state of the endothelium, which is well known as the indication of early stage formation of atherosclerosis (plaque formation and hardening of the arteries) . Plaque rupture can produce blood clots that block the arteries finally leading to thrombosis in coronary arteries (myocardial infarction or heart attack), carotid arteries (stroke), renal arteries (chronic kidney diseases) and in peripheral arteries (usually legs). Studies have also indicated the importance of endothelial dysfunction in the pathogenesis of dengue and leptospirosis (rat fever) , both of which are common diseases in Sri Lanka. A device which identifies and quantifies endothelial dysfunction may have a predictive value in diagnosing severe disease states of these infections. Moreover, since endothelial dysfunction is reversible, its early detection and quantification may have greater therapeutic and prognostic value. Methods to study endothelial dysfunction range from invasive methods such as coronary endothelial function testing and venous occlusion plethysmography to non-invasive methods such as brachial artery reactivity test, peripheral artery tonometry, pulse wave analysis, pulse contour analysis with digital volume pulse and digital thermal monitoring . The focus of this research is the development of a methodology to study endothelial dysfunction by thermal monitoring at the fingertip, which has shown promising results and is non-invasive in nature.
Expected outcomes: A device that measures blood volume and temperature signals at the fingertip and measure the health of endothelial function, an analysis of these signals to identify correlations with endothelial function